Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV Study

BACKGROUND: Type-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, we hypothesized that dysregulations in splicing machinery could precede, cont...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Gahete, Manuel D., del Rio-Moreno, Mercedes, Camargo, Antonio, Alcala-Diaz, Juan F., Alors-Perez, Emilia, Delgado-Lista, Javier, Reyes, Oscar, Ventura, Sebastian, Perez-Martínez, Pablo, Castaño, Justo P., Lopez-Miranda, José, Luque, Raul M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286259/
https://ncbi.nlm.nih.gov/pubmed/30446432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.10.056
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