Human COX7A2L Regulates Complex III Biogenesis and Promotes Supercomplex Organization Remodeling without Affecting Mitochondrial Bioenergetics

The mitochondrial respiratory chain is organized in a dynamic set of supercomplexes (SCs). The COX7A2L protein is essential for mammalian SC III(2)+IV assembly. However, its function in respirasome (SCs I+III(2)+IV(n)) biogenesis remains controversial. To unambiguously determine the COX7A2L role, we...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Lobo-Jarne, Teresa, Nývltová, Eva, Pérez-Pérez, Rafael, Timón-Gómez, Alba, Molinié, Thibaut, Choi, Austin, Mourier, Arnaud, Fontanesi, Flavia, Ugalde, Cristina, Barrientos, Antoni
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286155/
https://ncbi.nlm.nih.gov/pubmed/30428348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.058
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