A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV

Interferon (IFN) inhibits HIV replication by inducing antiviral effectors. To comprehensively identify IFN-induced HIV restriction factors, we assembled a CRISPR sgRNA library of Interferon Stimulated Genes (ISGs) into a modified lentiviral vector that allows for packaging of sgRNA-encoding genomes...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: OhAinle, Molly, Helms, Louisa, Vermeire, Jolien, Roesch, Ferdinand, Humes, Daryl, Basom, Ryan, Delrow, Jeffrey J, Overbaugh, Julie, Emerman, Michael
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2018
Sujets:
Microbiology and Infectious Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286125/
https://ncbi.nlm.nih.gov/pubmed/30520725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39823
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