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Anti-retroelement Activity of APOBEC3H was Lost Twice in Recent Human Evolution
The primate APOBEC3 gene locus encodes a family of proteins (APOBEC3A-H) with various antiviral and anti-retroelement activities. Here, we trace the evolution of APOBEC3H activity in hominoids to identify a human-specific loss of APOBEC3H antiviral activity. Reconstruction of the predicted ancestral...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2608726/ https://ncbi.nlm.nih.gov/pubmed/18779051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.07.005 |
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