Carriers of the PCSK9 R46L variant are characterized by an anti-atherogenic lipoprotein profile assessed by nuclear magnetic resonance spectroscopy

OBJECTIVE: Carriers of the PCSK9 R46L genetic variant (rs11591147) are characterized by low levels of low-density lipoprotein cholesterol and a decreased risk of cardiovascular disease (CVD). We studied the impact of the R46L variant on lipoprotein size and composition. APPROACH AND RESULTS: Lipopro...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Verbeek, Rutger, Boyer, Marjorie, Boekholdt, S. Matthijs, Hovingh, G. Kees, Kastelein, John J.P., Wareham, Nicholas, Khaw, Kay-Tee, Arsenault, Benoit J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284798/
https://ncbi.nlm.nih.gov/pubmed/27856457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307995
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