Natural product pectolinarigenin inhibits proliferation, induces apoptosis, and causes G2/M phase arrest of HCC via PI3K/AKT/mTOR/ERK signaling pathway

BACKGROUND: Hepatocellular carcinoma (HCC) is characterized by considerable phenotypic and molecular heterogeneity, but the overall survival of HCC patients remains extremely poor. Thus, novel and efficient alternatives to antitumor agents are urgently needed. Pectolinarigenin, a flavonoid compound...

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Vydáno v:Onco Targets Ther
Hlavní autoři: Wu, Tianchun, Dong, Xiaogang, Yu, Dongdong, Shen, Zhenhua, Yu, Jinbei, Yan, Sheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2018
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284530/
https://ncbi.nlm.nih.gov/pubmed/30584322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S186186
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