Neprilysin inhibition in mouse islets enhances insulin secretion in a GLP-1 receptor dependent manner

Neprilysin, a widely expressed peptidase upregulated in type 2 diabetes, is capable of cleaving and inactivating the insulinotropic glucagon-like peptide-1 (GLP-1). Like dipeptidyl peptidase-4 (DPP-4), inhibition of neprilysin activity under diabetic conditions is associated with increased active GL...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Islets
Asıl Yazarlar: Esser, Nathalie, Barrow, Breanne M., Choung, Edwina, Shen, Nancy J., Zraika, Sakeneh
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2018
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284476/
https://ncbi.nlm.nih.gov/pubmed/30142012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19382014.2018.1502521
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