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Neprilysin inhibition in mouse islets enhances insulin secretion in a GLP-1 receptor dependent manner
Neprilysin, a widely expressed peptidase upregulated in type 2 diabetes, is capable of cleaving and inactivating the insulinotropic glucagon-like peptide-1 (GLP-1). Like dipeptidyl peptidase-4 (DPP-4), inhibition of neprilysin activity under diabetic conditions is associated with increased active GL...
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| Publicado no: | Islets |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6284476/ https://ncbi.nlm.nih.gov/pubmed/30142012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19382014.2018.1502521 |
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