A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease

Susceptibility to multiple autoimmune diseases is associated with common gene polymorphisms influencing IL-2 signaling and T(reg) function, making T(reg)-specific expansion by IL-2 a compelling therapeutic approach to treatment. As an in vivo IL-2 half-life enhancer we used a non-targeted, effector-...

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Vydáno v:J Autoimmun
Hlavní autoři: Peterson, Laurence B., Bell, Charles J.M., Howlett, Sarah K., Pekalski, Marcin L., Brady, Kevin, Hinton, Heather, Sauter, Denise, Todd, John A., Umana, Pablo, Ast, Oliver, Waldhauer, Inja, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Klein, Christian, Hosse, Ralf J., Wicker, Linda S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Academic Press 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284106/
https://ncbi.nlm.nih.gov/pubmed/30446251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2018.10.017
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