The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein

Hypoxia-inducible transcription factors (HIFs) drive angiogenesis and cancer cell growth, contributing to an aggressive tumor phenotype. HIF-α protein levels and activity are controlled at the post-translational level by HIF hydroxylases. Hydroxylated HIF-α is recognized by the von Hippel Lindau (VH...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Wohlrab, Christina, Vissers, Margreet C. M., Phillips, Elisabeth, Morrin, Helen, Robinson, Bridget A., Dachs, Gabi U.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284050/
https://ncbi.nlm.nih.gov/pubmed/30555801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00574
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