Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation

Notch hyperactivation dominates T-cell acute lymphoblastic leukemia development, but the mechanisms underlying “pre-leukemic” cell dissemination are still unclear. Here we describe how deregulated Notch3 signaling enhances CXCR4 cell-surface expression and migratory ability of CD4(+)CD8(+) thymocyte...

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Udgivet i:Oncogene
Main Authors: Ferrandino, Francesca, Bernardini, Giovanni, Tsaouli, Georgia, Grazioli, Paola, Campese, Antonio Francesco, Noce, Claudia, Ciuffetta, Ambra, Vacca, Alessandra, Besharat, Zein Mersini, Bellavia, Diana, Screpanti, Isabella, Felli, Maria Pia
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284016/
https://ncbi.nlm.nih.gov/pubmed/30038265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0401-2
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