Hepatic Mitochondrial Defects in a Nonalcoholic Fatty Liver Disease Mouse Model Are Associated with Increased Degradation of Oxidative Phosphorylation Subunits

Nonalcoholic fatty liver disease (NAFLD) is associated with hepatic mitochondrial dysfunction characterized by reduced ATP synthesis. We applied the (2)H(2)O-metabolic labeling approach to test the hypothesis that the reduced stability of oxidative phosphorylation proteins contributes to mitochondri...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Lee, Kwangwon, Haddad, Andrew, Osme, Abdullah, Kim, Chunki, Borzou, Ahmad, Ilchenko, Sergei, Allende, Daniela, Dasarathy, Srinivasan, McCullough, Arthur, Sadygov, Rovshan G., Kasumov, Takhar
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283295/
https://ncbi.nlm.nih.gov/pubmed/30171159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000961
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