Antibody adsorption in protein‐A affinity chromatography – in situ measurement of nanoscale structure by small‐angle X‐ray scattering

Protein‐A chromatography is the most widely used chromatography step in downstream processing of antibodies. A deeper understanding of the influence of the surface topology on a molecular/nanoscale level on adsorption is essential for further improvement. It is not clear if the binding is homogenous...

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Bibliografiske detaljer
Udgivet i:J Sep Sci
Main Authors: Plewka, Jacek, Silva, Gonçalo L., Tscheließnig, Rupert, Rennhofer, Harald, Dias‐Cabral, Cristina, Jungbauer, Alois, Lichtenegger, Helga C.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Liquid Chromatography
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282589/
https://ncbi.nlm.nih.gov/pubmed/30240534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jssc.201800776
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