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Signaling of free fatty acid receptors 2 and 3 differs in colonic mucosa following selective agonism or coagonism by luminal propionate

BACKGROUND: Propionate exhibits affinity for free fatty acid receptor 2 (FFA2, formerly GPR43) and FFA3 (GPR41). These two G protein‐coupled receptors (GPCRs) are expressed by enteroendocrine L cells that contain anorectic peptide YY (PYY) and glucagon‐like peptide 1 (GLP‐1), while FFA3 is also expr...

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Détails bibliographiques
Publié dans:Neurogastroenterol Motil
Auteurs principaux: Tough, Iain R., Forbes, Sarah, Cox, Helen M.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282569/
https://ncbi.nlm.nih.gov/pubmed/30136343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nmo.13454
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