Forecasting Clinical Dose–Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin

A crucial step for accelerating tuberculosis drug development is bridging the gap between preclinical and clinical trials. In this study, we developed a preclinical model‐informed translational approach to predict drug effects across preclinical systems and early clinical trials using the in vitro‐b...

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Detalles Bibliográficos
Publicado en:Clin Pharmacol Ther
Main Authors: Wicha, Sebastian G., Clewe, Oskar, Svensson, Robin J., Gillespie, Stephen H., Hu, Yanmin, Coates, Anthony R.M., Simonsson, Ulrika S.H.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282494/
https://ncbi.nlm.nih.gov/pubmed/29700814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1102
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