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A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis

Proper characterization of drug effects on Mycobacterium tuberculosis relies on the characterization of phenotypically resistant bacteria to correctly establish exposure–response relationships. The aim of this work was to evaluate the potential difference in phenotypic resistance in in vitro compare...

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Bibliografiska uppgifter
I publikationen:J Pharmacokinet Pharmacodyn
Huvudupphovsmän: Clewe, Oskar, Faraj, Alan, Hu, Yanmin, Coates, Anthony R. M., Simonsson, Ulrika S. H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer US 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7520421/
https://ncbi.nlm.nih.gov/pubmed/32488575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-020-09694-0
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