Homotypic and Heterotypic Activation of the Notch Pathway in Multiple Myeloma–Enhanced Angiogenesis: A Novel Therapeutic Target?()

Interactions of multiple myeloma (MM) cells with endothelial cells (ECs) enhance angiogenesis and MM progression. Here, we investigated the role of Notch signaling in the cross talk between ECs and MM cells enabling angiogenesis. MMECs showed higher expression of Jagged1/2 ligands, of activated Notc...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Saltarella, Ilaria, Frassanito, Maria Antonia, Lamanuzzi, Aurelia, Brevi, Arianna, Leone, Patrizia, Desantis, Vanessa, Di Marzo, Lucia, Bellone, Matteo, Derudas, Daniele, Ribatti, Domenico, Chiaramonte, Raffaella, Palano, Maria Teresa, Neri, Antonino, Mariggiò, Maria Addolorata, Fumarulo, Ruggiero, Dammacco, Franco, Racanelli, Vito, Vacca, Angelo, Ria, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2018
Assuntos:
Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282459/
https://ncbi.nlm.nih.gov/pubmed/30529074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2018.10.011
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