uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis

The development of new lymphatic vessels occurs in many cancerous and inflammatory diseases through the binding of VEGF-C to its receptors, VEGFR-2 and VEGFR-3. The regulation of VEGFR-2/VEGFR-3 heterodimerisation and its downstream signaling in lymphatic endothelial cells (LECs) remain poorly under...

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Publié dans:Nat Commun
Auteurs principaux: Durré, Tania, Morfoisse, Florent, Erpicum, Charlotte, Ebroin, Marie, Blacher, Silvia, García-Caballero, Melissa, Deroanne, Christophe, Louis, Thomas, Balsat, Cédric, Van de Velde, Maureen, Kaijalainen, Seppo, Kridelka, Frédéric, Engelholm, Lars, Struman, Ingrid, Alitalo, Kari, Behrendt, Niels, Paupert, Jenny, Noel, Agnès
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281649/
https://ncbi.nlm.nih.gov/pubmed/30518756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07514-1
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