Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer

BRD4 assembles transcriptional machinery at gene super-enhancer regions and governs the expression of genes that are critical for cancer progression. However, it remains unclear whether BRD4-mediated gene transcription is required for tumor cells to develop drug resistance. Our data show that prolon...

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Udgivet i:Nat Commun
Main Authors: Liu, Jingyi, Duan, Zhibing, Guo, Weijie, Zeng, Lei, Wu, Yadi, Chen, Yule, Tai, Fang, Wang, Yifan, Lin, Yiwei, Zhang, Qiang, He, Yanling, Deng, Jiong, Stewart, Rachel L., Wang, Chi, Lin, Pengnian Charles, Ghaffari, Saghi, Evers, B. Mark, Liu, Suling, Zhou, Ming-Ming, Zhou, Binhua P., Shi, Jian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281582/
https://ncbi.nlm.nih.gov/pubmed/30518851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07258-y
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