H3K27me3 induces multidrug resistance in small cell lung cancer by affecting HOXA1 DNA methylation via regulation of the lncRNA HOTAIR

BACKGROUND: The long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) serves as a powerful predictor of tumor progression and overall survival in patients. Our previous studies showed that HOTAIR modulated HOXA1 DNA methylation by reducing DNMT1 and DNMT3b expression in drug-resistant s...

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Detalhes bibliográficos
Publicado no:Ann Transl Med
Main Authors: Fang, Shun, Shen, Yefeng, Chen, Bin, Wu, Yuanzhou, Jia, Longfei, Li, Yaling, Zhu, Yaru, Yan, Yusheng, Li, Man, Chen, Rui, Guo, Linlang, Chen, Xin, Chen, Qunqing
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281536/
https://ncbi.nlm.nih.gov/pubmed/30596070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2018.10.21
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