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Identification of rare levels of methylated tumor DNA fragments using an optimized bias based pre-amplification-digital droplet PCR (OBBPA-ddPCR)

BACKGROUND: The analysis of aberrant DNA methylations is used for the diagnosis of cancer as significant changes in the gene methylation pattern are often detected during early carcinogenesis. In this study, we evaluated the performance of a two-step method that combines pre-amplification with ddPCR...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Menschikowski, Mario, Jandeck, Carsten, Friedemann, Markus, Nacke, Brit, Hantsche, Saskia, Tiebel, Oliver, Sukocheva, Olga, Hagelgans, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281424/
https://ncbi.nlm.nih.gov/pubmed/30546833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26315
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