Monitoring BRAF and NRAS mutations with cell-free circulating tumor DNA from metastatic melanoma patients

The mutation status of the BRAF and NRAS genes in tumor tissue is used to select patients with metastatic melanoma for targeted therapy. Cell-free circulating DNA (cfDNA) represents an accessible, non-invasive surrogate sample that could provide a snapshot of the BRAF and NRAS genotype in these pati...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Long-Mira, Elodie, Ilie, Marius, Chamorey, Emmanuel, Leduff-Blanc, Florence, Montaudié, Henri, Tanga, Virginie, Allégra, Maryline, Lespinet-Fabre, Virginie, Bordone, Olivier, Bonnetaud, Christelle, Schiappa, Renaud, Butori, Catherine, Bence, Coraline, Lacour, Jean-Philippe, Hofman, Véronique, Hofman, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281416/
https://ncbi.nlm.nih.gov/pubmed/30546839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26343
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