Monitoring BRAF and NRAS mutations with cell-free circulating tumor DNA from metastatic melanoma patients

The mutation status of the BRAF and NRAS genes in tumor tissue is used to select patients with metastatic melanoma for targeted therapy. Cell-free circulating DNA (cfDNA) represents an accessible, non-invasive surrogate sample that could provide a snapshot of the BRAF and NRAS genotype in these pati...

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Pubblicato in:Oncotarget
Autori principali: Long-Mira, Elodie, Ilie, Marius, Chamorey, Emmanuel, Leduff-Blanc, Florence, Montaudié, Henri, Tanga, Virginie, Allégra, Maryline, Lespinet-Fabre, Virginie, Bordone, Olivier, Bonnetaud, Christelle, Schiappa, Renaud, Butori, Catherine, Bence, Coraline, Lacour, Jean-Philippe, Hofman, Véronique, Hofman, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281416/
https://ncbi.nlm.nih.gov/pubmed/30546839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26343
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