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Restoration of Type I Interferon Expression by Heme and Related Tetrapyrroles Through Inhibition of NS3/4A Protease

Background. Tetrapyrrole substrates and products of heme oxygenase are potent inhibitors of hepatitis C virus (HCV) replication. It is not clear whether this occurs through primary induction of type I interferon (IFN), inhibition of viral NS3/4A protease, or a combination of these mechanisms. We stu...

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Bibliografiske detaljer
Udgivet i:J Infect Dis
Main Authors: Zhu, Zhaowen, Mathahs, M. Meleah, Schmidt, Warren N.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281408/
https://ncbi.nlm.nih.gov/pubmed/23901085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit338
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