Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment

A normal endowment of nephrons in the mammalian kidney requires a balance of nephron progenitor self-renewal and differentiation throughout development. Here, we provide evidence for a novel action of ureteric branch tip-derived Wnt11 in progenitor cell organization and interactions within the nephr...

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Bibliographic Details
Published in:eLife
Main Authors: O'Brien, Lori L, Combes, Alexander N, Short, Kieran M, Lindström, Nils O, Whitney, Peter H, Cullen-McEwen, Luise A, Ju, Adler, Abdelhalim, Ahmed, Michos, Odyssé, Bertram, John F, Smyth, Ian M, Little, Melissa H, McMahon, Andrew P
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281319/
https://ncbi.nlm.nih.gov/pubmed/30516471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40392
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