Analysis of NK cell clones obtained using interleukin-2 and gene-modified K562 cells revealed the ability of “senescent” NK cells to lose CD57 expression and start expressing NKG2A

In this work, we analyzed the phenotype and growth of human NK cell clones obtained by the stimulation of individual NK cells with IL-2 and gene-modified K562 feeder cells expressing membrane-bound IL-21 (K562-mbIL21). We generated clones from NK cells at distinct differentiation and activation stag...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Streltsova, Maria A., Erokhina, Sofya A., Kanevskiy, Leonid M., Lee, Dean A., Telford, William G., Sapozhnikov, Alexander M., Kovalenko, Elena I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281266/
https://ncbi.nlm.nih.gov/pubmed/30517188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208469
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