Longer TOMM40 poly-T variants associated with higher FDDNP-PET medial temporal tau and amyloid binding

BACKGROUND: The translocase of outer mitochondrial membrane 40 (TOMM40), which lies in linkage disequilibrium with the apolipoprotein E (APOE) gene, has been implicated in Alzheimer’s disease (AD). TOMM40 influences AD pathology through mitochondrial neurotoxicity, and the medial temporal lobe (MTL)...

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Publicat a:PLoS One
Autors principals: Siddarth, Prabha, Burggren, Alison C., Merrill, David A., Ercoli, Linda M., Mahmood, Zanjbeel, Barrio, Jorge R., Small, Gary W.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281258/
https://ncbi.nlm.nih.gov/pubmed/30517207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208358
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