Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

A hallmark of aging is a decline in metabolic homeostasis, which is attenuated by dietary restriction (DR). However, the interaction of aging and DR with the metabolome is not well understood. We report that DR is a stronger modulator of the rat metabolome than age in plasma and tissues. A comparati...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Walters, Ryan O., Arias, Esperanza, Diaz, Antonio, Burgos, Emmanuel S., Guan, Fangxia, Tiano, Simoni, Mao, Kai, Green, Cara L., Qiu, Yungping, Shah, Hardik, Wang, Donghai, Hudgins, Adam D., Tabrizian, Tahmineh, Tosti, Valeria, Shechter, David, Fontana, Luigi, Kurland, Irwin J., Barzilai, Nir, Cuervo, Ana Maria, Promislow, Daniel E.L., Huffman, Derek M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280974/
https://ncbi.nlm.nih.gov/pubmed/30332646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.09.065
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