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Role for intraflagellar transport in building a functional transition zone

Genetic disorders caused by cilia dysfunction, termed ciliopathies, frequently involve the intraflagellar transport (IFT) system. Mutations in IFT subunits—including IFT‐dynein motor DYNC2H1—impair ciliary structures and Hedgehog signalling, typically leading to “skeletal” ciliopathies such as Jeune...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Jensen, Victor L, Lambacher, Nils J, Li, Chunmei, Mohan, Swetha, Williams, Corey L, Inglis, Peter N, Yoder, Bradley K, Blacque, Oliver E, Leroux, Michel R
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280794/
https://ncbi.nlm.nih.gov/pubmed/30429209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201845862
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