Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP(2) ciliary abundance

Cilia are thought to harbour a membrane diffusion barrier within their transition zone (TZ) that compartmentalises signalling proteins. How this “ciliary gate” assembles and functions remains largely unknown. Contrary to current models, we present evidence that Caenorhabditis elegans MKS-5 (ortholog...

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Bibliographic Details
Published in:EMBO J
Main Authors: Jensen, Victor L, Li, Chunmei, Bowie, Rachel V, Clarke, Lara, Mohan, Swetha, Blacque, Oliver E, Leroux, Michel R
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609185/
https://ncbi.nlm.nih.gov/pubmed/26392567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488044
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