β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders

G protein coupled receptors (GPCRs) were first characterized as signal transducers that elicit downstream effects through modulation of guanine (G) nucleotide-binding proteins. The pharmacotherapeutic exploitation of this signaling paradigm has created a drug-based field covering nearly 50% of the c...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: van Gastel, Jaana, Hendrickx, Jhana O., Leysen, Hanne, Santos-Otte, Paula, Luttrell, Louis M., Martin, Bronwen, Maudsley, Stuart
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280185/
https://ncbi.nlm.nih.gov/pubmed/30546309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01369
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