Isoorientin Ameliorates APAP-Induced Hepatotoxicity via Activation Nrf2 Antioxidative Pathway: The Involvement of AMPK/Akt/GSK3β

Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been shown to have antioxidant potential. However, the effect of Iso on APAP-induced liver injury has not yet been elucidated. Th...

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Publicat a:Front Pharmacol
Autors principals: Fan, Xiaoye, Lv, Hongming, Wang, Lidong, Deng, Xuming, Ci, Xinxin
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279939/
https://ncbi.nlm.nih.gov/pubmed/30546306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01334
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