3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming interdigitating foot processes with intervening slit diaphragms, disruption in which results in proteinuria. Studies into human podocytopathies to date have employed primary or immortalised podocyte cell line...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Hale, Lorna J., Howden, Sara E., Phipson, Belinda, Lonsdale, Andrew, Er, Pei X., Ghobrial, Irene, Hosawi, Salman, Wilson, Sean, Lawlor, Kynan T., Khan, Shahnaz, Oshlack, Alicia, Quinlan, Catherine, Lennon, Rachel, Little, Melissa H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279764/
https://ncbi.nlm.nih.gov/pubmed/30514835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07594-z
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