Expression of STING Is Increased in Liver Tissues from Patients With NAFLD and Promotes Macrophage-mediated Hepatic Inflammation and Fibrosis in Mice

BACKGROUND & AIMS: Transmembrane protein 173 (TMEM173 or STING) signaling by macrophage activates the type I interferon-mediated innate immune response. The innate immune response contributes to hepatic steatosis and non-alcoholic fatty liver disease (NAFLD). We investigated wither STING regulat...

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Vydáno v:Gastroenterology
Hlavní autoři: Luo, Xianjun, Li, Honggui, Ma, Linqiang, Zhou, Jing, Guo, Xin, Woo, Shih-Lung, Pei, Ya, Knight, Linda R., Deveau, Michael, Chen, Yanming, Qian, Xiaoxian, Xiao, Xiaoqiu, Li, Qifu, Chen, Xiangbai, Huo, Yuqing, McDaniel, Kelly, Francis, Heather, Glaser, Shannon, Meng, Fanyin, Alpini, Gianfranco, Wu, Chaodong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279491/
https://ncbi.nlm.nih.gov/pubmed/30213555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.09.010
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