Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA. We identified fragile X mental retardation protein (FMRP) as...

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Опубликовано в: :eLife
Главные авторы: Soto-Acosta, Ruben, Xie, Xuping, Shan, Chao, Baker, Coleman K, Shi, Pei-Yong, Rossi, Shannan L, Garcia-Blanco, Mariano A, Bradrick, Shelton
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2018
Предметы:
Chromosomes and Gene Expression
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279352/
https://ncbi.nlm.nih.gov/pubmed/30511641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39023
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