MDM2- and FLT3-inhibitors in the treatment of FLT3-ITD acute myeloid leukemia, specificity and efficacy of NVP-HDM201 and midostaurin

Prognosis for FLT3-ITD positive acute myeloid leukemia with high allelic ratio (>0.5) is poor, particularly in relapse, refractory to or unfit for intensive treatment, thus highlighting an unmet need for novel therapeutic approaches. The combined use of compounds targeting both the mutated FLT3 r...

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Udgivet i:Haematologica
Main Authors: Seipel, Katja, Marques, Miguel A.T., Sidler, Corinne, Mueller, Beatrice U., Pabst, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278968/
https://ncbi.nlm.nih.gov/pubmed/29976747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.191650
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