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Reduced structural flexibility for an exonuclease deficient DNA polymerase III mutant†
DNA synthesis, carried out by DNA polymerases, requires balancing speed and accuracy for faithful replication of the genome. High fidelity DNA polymerases contain a 3′–5′ exonuclease domain that can remove misincorporated nucleotides on the 3′ end of the primer strand, a process called proofreading....
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| Publicat a: | Phys Chem Chem Phys |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6278910/ https://ncbi.nlm.nih.gov/pubmed/30345999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cp04112a |
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