Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect

BACKGROUND: Naphthalene-etomidate, an etomidate analog containing a bulky phenyl ring substituent group, possesses very low γ-aminobutyric acid type A (GABA(A)) receptor efficacy and acts as an anesthetic-selective competitive antagonist. Using etomidate analogs containing phenyl ring substituents g...

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Veröffentlicht in:Anesthesiology
Hauptverfasser: McGrath, Megan, Yu, Zhiyi, Jayakar, Selwyn S., Ma, Celena, Tolia, Mansi, Zhou, Xiaojuan, Miller, Keith W., Cohen, Jonathan B., Raines, Douglas E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278829/
https://ncbi.nlm.nih.gov/pubmed/30052529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002356
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