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Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction
The CRISPR-Cas9 system is attractive for gene therapy, as it allows for permanent genetic correction. However, as a new technology, Cas9 gene editing in clinical applications faces major challenges, such as safe delivery and gene targeting efficiency. Cas9 is a foreign protein to recipient cells; th...
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| Publicat a: | Mol Ther Nucleic Acids |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Gene & Cell Therapy
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6278715/ https://ncbi.nlm.nih.gov/pubmed/30513454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.10.015 |
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