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Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction

The CRISPR-Cas9 system is attractive for gene therapy, as it allows for permanent genetic correction. However, as a new technology, Cas9 gene editing in clinical applications faces major challenges, such as safe delivery and gene targeting efficiency. Cas9 is a foreign protein to recipient cells; th...

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Bibliografiske detaljer
Udgivet i:Mol Ther Nucleic Acids
Main Authors: Xia, Emily, Duan, Rongqi, Shi, Fushan, Seigel, Kyle E., Grasemann, Hartmut, Hu, Jim
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278715/
https://ncbi.nlm.nih.gov/pubmed/30513454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.10.015
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