Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP

Maritoclax, an active constituent isolated from marine bacteria, has been known to induce Mcl-1 downregulation through proteasomal degradation. In this study, we investigated the sensitizing effect of maritoclax on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Jeon, Mi-Yeon, Min, Kyoung-jin, Woo, Seon Min, Seo, Seung Un, Choi, Yung Hyun, Kim, Sang Hyun, Kim, Dong Eun, Lee, Tae-Jin, Kim, Shin, Park, Jong-Wook, Kwon, Taeg Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278439/
https://ncbi.nlm.nih.gov/pubmed/30463333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23113030
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