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The Contribution of the Descending Pain Modulatory Pathway in Opioid Tolerance

Opioids remain among the most effective pain-relieving therapeutics. However, their long-term use is limited due to the development of tolerance and potential for addiction. For many years, researchers have explored the underlying mechanisms that lead to this decreased effectiveness of opioids after...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Lueptow, Lindsay M., Fakira, Amanda K., Bobeck, Erin N.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278175/
https://ncbi.nlm.nih.gov/pubmed/30542261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00886
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