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The Contribution of the Descending Pain Modulatory Pathway in Opioid Tolerance

Opioids remain among the most effective pain-relieving therapeutics. However, their long-term use is limited due to the development of tolerance and potential for addiction. For many years, researchers have explored the underlying mechanisms that lead to this decreased effectiveness of opioids after...

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Vydáno v:Front Neurosci
Hlavní autoři: Lueptow, Lindsay M., Fakira, Amanda K., Bobeck, Erin N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278175/
https://ncbi.nlm.nih.gov/pubmed/30542261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00886
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