Virulence of Mycobacterium tuberculosis Clinical Isolates Is Associated With Sputum Pre-treatment Bacterial Load, Lineage, Survival in Macrophages, and Cytokine Response

It is uncertain whether differences in Mycobacterium tuberculosis (Mtb) virulence defined in vitro influence clinical tuberculosis pathogenesis, transmission, and mortality. We primarily used a macrophage lysis model to characterize the virulence of Mtb isolates collected from 153 Vietnamese adults...

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Dettagli Bibliografici
Pubblicato in:Front Cell Infect Microbiol
Autori principali: Tram, Trinh T. B., Nhung, Hoang N., Vijay, Srinivasan, Hai, Hoang T., Thu, Do D. A., Ha, Vu T. N., Dinh, Tran D., Ashton, Philip M., Hanh, Nguyen T., Phu, Nguyen H., Thwaites, Guy E., Thuong, Nguyen T. T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Cellular and Infection Microbiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277702/
https://ncbi.nlm.nih.gov/pubmed/30538956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00417
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