Virulence of Mycobacterium tuberculosis Clinical Isolates Is Associated With Sputum Pre-treatment Bacterial Load, Lineage, Survival in Macrophages, and Cytokine Response

It is uncertain whether differences in Mycobacterium tuberculosis (Mtb) virulence defined in vitro influence clinical tuberculosis pathogenesis, transmission, and mortality. We primarily used a macrophage lysis model to characterize the virulence of Mtb isolates collected from 153 Vietnamese adults...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Tram, Trinh T. B., Nhung, Hoang N., Vijay, Srinivasan, Hai, Hoang T., Thu, Do D. A., Ha, Vu T. N., Dinh, Tran D., Ashton, Philip M., Hanh, Nguyen T., Phu, Nguyen H., Thwaites, Guy E., Thuong, Nguyen T. T.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Cellular and Infection Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277702/
https://ncbi.nlm.nih.gov/pubmed/30538956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00417
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