Virulence of Mycobacterium tuberculosis Clinical Isolates Is Associated With Sputum Pre-treatment Bacterial Load, Lineage, Survival in Macrophages, and Cytokine Response

It is uncertain whether differences in Mycobacterium tuberculosis (Mtb) virulence defined in vitro influence clinical tuberculosis pathogenesis, transmission, and mortality. We primarily used a macrophage lysis model to characterize the virulence of Mtb isolates collected from 153 Vietnamese adults...

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Bibliographic Details
Published in:Front Cell Infect Microbiol
Main Authors: Tram, Trinh T. B., Nhung, Hoang N., Vijay, Srinivasan, Hai, Hoang T., Thu, Do D. A., Ha, Vu T. N., Dinh, Tran D., Ashton, Philip M., Hanh, Nguyen T., Phu, Nguyen H., Thwaites, Guy E., Thuong, Nguyen T. T.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Cellular and Infection Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277702/
https://ncbi.nlm.nih.gov/pubmed/30538956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00417
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