Virulence of Mycobacterium tuberculosis Clinical Isolates Is Associated With Sputum Pre-treatment Bacterial Load, Lineage, Survival in Macrophages, and Cytokine Response

It is uncertain whether differences in Mycobacterium tuberculosis (Mtb) virulence defined in vitro influence clinical tuberculosis pathogenesis, transmission, and mortality. We primarily used a macrophage lysis model to characterize the virulence of Mtb isolates collected from 153 Vietnamese adults...

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Detalles Bibliográficos
Publicado en:Front Cell Infect Microbiol
Main Authors: Tram, Trinh T. B., Nhung, Hoang N., Vijay, Srinivasan, Hai, Hoang T., Thu, Do D. A., Ha, Vu T. N., Dinh, Tran D., Ashton, Philip M., Hanh, Nguyen T., Phu, Nguyen H., Thwaites, Guy E., Thuong, Nguyen T. T.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Cellular and Infection Microbiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277702/
https://ncbi.nlm.nih.gov/pubmed/30538956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00417
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