Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

Statins are inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis, and have been clinically used to treat cardiovascular disease. However, a paradoxical increase of reductase protein following statin treatment may attenuate the effect and increase the side effects. He...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Jiang, Shi-You, Li, Hui, Tang, Jing-Jie, Wang, Jie, Luo, Jie, Liu, Bing, Wang, Jin-Kai, Shi, Xiong-Jie, Cui, Hai-Wei, Tang, Jie, Yang, Fan, Qi, Wei, Qiu, Wen-Wei, Song, Bao-Liang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277434/
https://ncbi.nlm.nih.gov/pubmed/30510211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07590-3
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