Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase

BACKGROUND: Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized. OBJECTIVES: This study sought to determine the molecular effects of statin therapy o...

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Bibliografske podrobnosti
izdano v:J Am Coll Cardiol
Main Authors: Würtz, Peter, Wang, Qin, Soininen, Pasi, Kangas, Antti J., Fatemifar, Ghazaleh, Tynkkynen, Tuulia, Tiainen, Mika, Perola, Markus, Tillin, Therese, Hughes, Alun D., Mäntyselkä, Pekka, Kähönen, Mika, Lehtimäki, Terho, Sattar, Naveed, Hingorani, Aroon D., Casas, Juan-Pablo, Salomaa, Veikko, Kivimäki, Mika, Järvelin, Marjo-Riitta, Davey Smith, George, Vanhala, Mauno, Lawlor, Debbie A., Raitakari, Olli T., Chaturvedi, Nish, Kettunen, Johannes, Ala-Korpela, Mika
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Biomedical 2016
Teme:
Original Investigation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783625/
https://ncbi.nlm.nih.gov/pubmed/26965542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2015.12.060
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