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Contribution of Inbred Singletons to Variance Component Estimation of Heritability and Linkage

OBJECTIVES: An interesting consequence of consanguinity is that the inbred singleton becomes informative for genetic variance. We determine the contribution of an inbred singleton to variance component analysis of heritability and linkage. METHODS: Statistical theory for the power of variance compon...

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Publicat a:Hum Hered
Autors principals: Blondell, Lucy, Blackburn, August, Kos, Mark Z., Blangero, John, Göring, Harald H. H.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277139/
https://ncbi.nlm.nih.gov/pubmed/30391948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000492830
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