A serological marker of the N-terminal neoepitope generated during LOXL2 maturation is elevated in patients with cancer or idiopathic pulmonary fibrosis

OBJECTIVES: Lysyl oxidase like 2 (LOXL2) is associated with poor prognosis in idiopathic pulmonary disease (IPF) and cancer. We developed an Enzyme-linked immunosorbent assay (ELISA) targeting the LOXL2 neo-epitope generated through the release of the signal peptide during LOXL2 maturation. DESIGN A...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Rep
Main Authors: Leeming, D.J., Willumsen, N., Sand, J.M.B., Holm Nielsen, S., Dasgupta, B., Brodmerkel, C., Curran, M., Bager, C.L., Karsdal, MA.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276730/
https://ncbi.nlm.nih.gov/pubmed/30555938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2018.11.002
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