Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV

Membrane-associated carbonic anhydrase (CA) isoform IV participates in carbon metabolism and pH homeostasis and is implicated in the development of eye diseases such as retinitis pigmentosa and glaucoma. A series of substituted benzenesulfonamides were designed and their binding affinity to CA IV wa...

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Publicado no:Eur Biophys J
Main Authors: Mickevičiūtė, Aurelija, Timm, David D., Gedgaudas, Marius, Linkuvienė, Vaida, Chen, Zhiwei, Waheed, Abdul, Michailovienė, Vilma, Zubrienė, Asta, Smirnov, Alexey, Čapkauskaitė, Edita, Baranauskienė, Lina, Jachno, Jelena, Revuckienė, Jurgita, Manakova, Elena, Gražulis, Saulius, Matulienė, Jurgita, Di Cera, Enrico, Sly, William S., Matulis, Daumantas
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276378/
https://ncbi.nlm.nih.gov/pubmed/28975383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00249-017-1256-0
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