NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury

Peripheral nerve lesions provoke apoptosis in the dorsal horn of the spinal cord. The cause of cell death, the involvement of neurons, and the relevance for the processing of somatosensory information are controversial. Here, we demonstrate in a mouse model of sciatic nerve injury that glutamate-ind...

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Udgivet i:Cell Rep
Main Authors: Inquimbert, Perrine, Moll, Martin, Latremoliere, Alban, Tong, Chi-Kun, Whang, John, Sheehan, Gregory F., Smith, Brendan M., Korb, Erica, Athié, Maria C.P., Babaniyi, Olusegun, Ghasemlou, Nader, Yanagawa, Yuchio, Allis, C. David, Hof, Patrick R., Scholz, Joachim
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276118/
https://ncbi.nlm.nih.gov/pubmed/29847798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.107
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