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Stability of the N-Terminal Helix and Its Role in Amyloid Formation of Serum Amyloid A

[Image: see text] Colonic amyloidosis is the result of overexpression of the serum amyloid A (SAA) protein in inflammatory bowel disease or colon cancer. Crucial for amyloid formation are the first ten N-terminal residues, which in the crystal structure are a part of a 27-residue long helix. Here, w...

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Publicat a:ACS Omega
Autors principals: Wang, Wenhua, Xi, Wenhui, Hansmann, Ulrich H. E.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2018
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275945/
https://ncbi.nlm.nih.gov/pubmed/30533585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b02377
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